Сообщение
A compound of formula VIII X is C R3; Y is C R1; R1 is H, D, or halogen; R2 is N R C O Cy2, N R S O 2Cy2, or N R Cy2; R3 is H or halogen; Cy1 is phenyl or a 5 6 membered monocyclic heteroaryl ring having 1 4 heteroatoms independently selected from nitrogen, oxygen, and sulfur; wherein Cy1 is substituted with n instances of R5; Cy2 is phenyl; a 5 6 membered monocyclic heteroaryl ring having 1 4 heteroatoms independently selected from nitrogen, oxygen, and sulfur; a 3 7 membered saturated or partially unsaturated heterocyclic ring having 1 2 heteroatoms independently selected from nitrogen, oxygen, and sulfur; or a 3 7 membered saturated or partially unsaturated monocyclic carbocyclic ring; wherein Cy2 is substituted with p instances of R6; Cy3 is a 5 6 membered monocyclic heteroaromatic ring having 1 4 heteroatoms independently selected from nitrogen, oxygen, and sulfur; wherein Cy3 is substituted with r instances of R8; L1 is N R; each instance of R4, R5, R6, R7 and R8 is independently RA or RB, and is substituted by q instances of Rc; each instance of RA is independently oxo, halogen, CN, NO2, OR, ORD, SR, NR2, S O 2R, S O 2NR2, S O R, S O NR2, C O R, C O OR, C O NR2, C O N R OR, OC O R, OC O NR2, N R C O OR, N R C O R, N R C O NR2, N R C NR NR2, N R S O 2NR2, or N R S O 2R; each instance of RB is independently C1 6 aliphatic; phenyl; a 5 6 membered monocyclic heteroaryl ring having 1 4 heteroatoms independently selected from nitrogen, oxygen, and sulfur; an 8 10 membered bicyclic heteroaryl ring having 1 4 heteroatoms independently selected from nitrogen, oxygen, and sulfur; a 3 7 membered saturated or partially unsaturated carbocyclic ring; a 3 7 membered saturated or partially unsaturated monocyclic heterocyclic ring having 1 2 heteroatoms independently selected from nitrogen, oxygen, and sulfur; or a 7 12 membered saturated or partially unsaturated bicyclic heterocyclic ring having 1 4 heteroatoms independently selected from nitrogen, oxygen, and sulfur; each instance of RC is independently oxo, halogen, CN, NO2, OR, SR, NR2, S O 2R, S O 2NR2, S O R, S O NR2, C O R, C O OR, C O NR2, C O N R OR, OC O R, OC O NR2, N R C O OR, N R C O R, N R C O NR2, N R C NR NR2, N R S O 2NR2, or N R S O 2R or an optionally substituted group selected from C1 6 aliphatic, phenyl, a 3 7 membered saturated or partially unsaturated heterocyclic ring having 1 2 heteroatoms independently selected from nitrogen, oxygen, and sulfur, and a 5 6 membered heteroaryl ring having 1 4 heteroatoms independently selected from nitrogen, oxygen, and sulfur; RD is a C1 4 aliphatic group wherein one or more hydrogens are replaced by deuterium; each R is independently hydrogen, or an optionally substituted group selected from C1 6 aliphatic, phenyl, a 3 7 membered saturated or partially unsaturated heterocyclic having 1 2 heteroatoms independently selected from nitrogen, oxygen, and sulfur, and a 5 6 membered heteroaryl ring having 1 4 heteroatoms independently selected from nitrogen, oxygen, and sulfur, or two R groups on the same nitrogen are taken together with their intervening atoms to form a 4 7 membered saturated, partially unsaturated, or heteroaryl ring having 0 3 heteroatoms, in addition to the nitrogen, independently selected from nitrogen, oxygen, and sulfur; and reviews on tamoxifen Administration of QTERNMET XR with a standard meal resulted in an increase in Tmax of metformin by 2 h and no effect on metformin Cmax as compared to fasted conditions
